New research shared at the American Society of Nephrology Kidney Week 2025 shows strong links between chronic kidney disease (CKD) and mental health problems such as depression and posttraumatic stress disorder (PTSD). These findings point to the need for more study on how mental illnesses and kidney disease affect each other.
CKD happens when damaged kidneys cannot remove waste properly or control blood pressure. Early on, CKD may not show symptoms. Later, signs can include changes in urination, feeling tired, nausea, and loss of appetite. In advanced stages, people may have trouble concentrating, swollen limbs, and muscle pain.
One study analyzed information from over 157,000 people in the UK. It found that people with CKD were more likely to have depression, anxiety, panic attacks, and eating disorders than those without CKD. Those with CKD and depression took more medication but used talk therapies like counseling less often.
Another study focused on US veterans with PTSD or major depressive disorder. It showed these mental health issues increased the risk of CKD and end-stage kidney disease (ESKD), which is a severe form of kidney failure. Veterans with PTSD or depression had higher rates of new kidney disease compared to those without these mental illnesses.
Pharmacists play an important role in helping patients with CKD and mental health problems. They can spot mental health disorders early by reviewing medications and checking for treatment adherence. Pharmacists also help adjust medications safely for those with kidney problems and support mental health treatments. Good mental health care improves how well patients follow their kidney treatment and slows disease progression.
The researchers stress that mental health conditions are serious risks for worsening kidney disease. Mental health therapists, pharmacists, and clinicians need to work together to better care for patients with these linked health challenges.
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