Testosterone supplementation in older men with low levels may modestly improve sexual function and mood, but it carries potential risks, especially to heart health. The decision to use testosterone boosters should be carefully discussed with a healthcare provider.
As men age, testosterone levels naturally decline, which can contribute to decreased libido, energy, mood changes, anemia, and bone weakness. To explore whether testosterone supplements could help, the National Institute on Aging sponsored the Testosterone Trials (T Trials), a series of clinical studies involving men 65 and older with low testosterone and related symptoms.
Key Findings from the Testosterone Trials
Sexual Function: Testosterone gel improved sexual activity, desire, and erectile function modestly in men with low testosterone and reduced libido.
Mood: Some improvement in depressive symptoms and overall mood was noted.
Physical and Vitality Function: Testosterone did not significantly improve walking ability or energy levels.
Anemia: Testosterone increased hemoglobin levels in men with low testosterone and unexplained anemia, suggesting a potential benefit.
Bone Health: Testosterone supplementation increased bone density and strength, especially in the spine.
Cognitive Function: Testosterone showed no benefit for age-related memory impairment.
Cardiovascular Health: Men using testosterone gel had increased noncalcified plaque buildup in heart arteries, which could raise the risk of heart problems.
Important Considerations
Testosterone levels fluctuate daily, so multiple morning blood tests are necessary to confirm low testosterone before starting therapy.
Testosterone is usually considered clinically low below about 230 nanograms per deciliter (ng/dL).
Long-term effects and safety of testosterone supplementation in older men remain unclear; further research is needed.
Men with prostate cancer, heart disease, or kidney problems are generally excluded from testosterone therapy trials due to potential risks.
Bottom Line
Testosterone boosters may offer some benefits for sexual health, mood, anemia, and bone strength in older men with low testosterone, but they also carry potential risks, particularly for heart health. Men considering testosterone supplementation should thoroughly discuss the pros and cons with their healthcare provider before starting treatment.
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