The American Cancer Society (ACS) has released its latest Prostate Cancer Statistics, 2025, showing troubling shifts in prostate cancer trends in the United States. After years of decline, incidence rates are once again climbing. From 2014 to 2021, overall rates rose by 3% per year, with advanced-stage cases increasing nearly 5% annually. At the same time, mortality reductions have slowed to less than 1% per year, compared with 3–4% per year during the 1990s and 2000s.
Racial and ethnic disparities remain stark
The report highlights deep disparities in prostate cancer outcomes. Black men face double the mortality rate of White men, despite only a 67% higher incidence. Native American men experience 12% higher mortality compared to White men, despite having lower incidence rates. Mortality also varies by state, with the highest death rates in Washington, D.C., and Mississippi—both with large Black populations.
Calls for earlier conversations about screening
“Our research underscores the urgency of addressing both the rising incidence and the persistent racial gaps in outcomes,” said Tyler Kratzer, MPH, lead author and ACS scientist. The ACS recommends men begin discussing prostate cancer screening with their doctors at age 50. Black men and those with a family history should start that conversation at age 45.
Scope of the disease
Prostate cancer remains the most common cancer among U.S. men, accounting for about 30% of male cancer cases in 2025. It is also the second-leading cause of cancer death in men, after lung cancer. This year alone, ACS projects 313,780 new cases and 35,770 deaths.
Survival depends on stage at diagnosis
Researchers found distant-stage prostate cancer is increasing across all age groups, including younger men under 55. The five-year survival rate is nearly 100% for early-stage disease but drops to 38% for advanced diagnoses.
Report highlights
- American Indian and Alaska Native men are most likely to be diagnosed with distant-stage disease (12% vs. 8% among White men).
- Mortality ranges from 36.9 deaths per 100,000 among Black men to 8.8 among Asian American and Pacific Islander men.
- State-level disparities persist, with Washington, D.C., and Mississippi recording the highest mortality rates.
Advocacy and policy efforts
The ACS Cancer Action Network (ACS CAN) is backing the PSA Screening for HIM Act, federal legislation that would eliminate out-of-pocket costs for prostate cancer screening in men at highest risk. “Cost should never stand in the way of early detection,” said Lisa A. Lacasse, President of ACS CAN. “This bill would help save lives and reduce disparities.”
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